Before answering these questions my drug is WARFARIN.
1) If a standard dose of your medication(Warfarin) is 28mg/kg how much of your medication(Warfarin) in
grams, would you give if your patient weighed 177 lbs?
2) If one tablet contain 1125 mg and the patient consumed 4 tablets did they overdose or
under-dose and by what factor (how much)?
3. Based on the pH of your drug, if your drug was in a high concentration in the blood,
how would it affect the pH of your blood. Would it cause acidosis or alkalosis, and how
would you treat this?
4. The blood brain barrier protects the brain from harmful molecules and also prohibits
certain drugs to cross as well. Only drugs who are hydrophobic are allowed to pass,
while those that are hydrophilic are kept out. Do you think your drug would pass
through the blood brain barrier based on its chemical make-up. Explain.
5. Quite often, medications cannot be taken with grapefruit juice. This is because
grapefruit juice blocks an enzyme responsible for metabolism of the drug. Chemicals in
grapefruit juice bind to the active site of the enzyme. What type of inhibition is this, and
what would it do to the amount of medication in your blood? Why is this bad, explain?
6. If blood sugar is too high (ate something very high in sucrose), based on the reactions
we have learned, what do you think is the first line of defense to lower blood sugar and
how would this tie into specific reaction(s) to lower blood sugar. Show the reaction and
its products.